Archives of Gerontology and Geriatrics
Volume 36, Issue 1 , Pages 23-35 , January 2003

Effect of age on the induction of 8-oxo-2′-deoxyguanosine-releasing enzyme in rat liver by γ-ray irradiation

  • Takao Kaneko

      Affiliations

    • Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +813-3964-3241; fax: +813-3579-4776
    • ,
  • Shoichi Tahara

      Affiliations

    • Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
    • ,
  • Munehiko Tanno

      Affiliations

    • Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
    • ,
  • Takahiko Taguchi

      Affiliations

    • Department of Gene Regulation and Protein Function, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan

Received 7 January 2002 ,Accepted 27 June 2002.

References 

  1. Ames BN. Dietary carcinogens and anticarcinogens. Science. 1983;221:1256–1264
  2. Arai K, Morishita K, Shinmura K, Kohno T, Kim S-R, Nohmi T, et al. Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene. 1997;14:2857–2861
  3. Aruoma OI, Halliwell B, Gajewski E, Dizdaroglu M. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J. Biol. Chem. 1989;264:20509–20512
  4. Bessho T, Tano K, Kasai H, Ohtsuka E, Nishimura S. Evidence for two repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. J. Biol. Chem. 1993;268:19416–19421
  5. Burger RM, Berkowitz AR, Peisach J, Horwitz SB. Origin of malondialdehyde from DNA degraded by Fe(II)-bleomycin. J. Biol. Chem. 1980;255:11832–11838
  6. Cardozo-Pelaez F, Brooks PJ, Stedeford T, Song S, Sanchez-Ramos J. DNA damage, repair, and antioxidant systems in brain regions: a correlative study. Free Radical Biol. Med. 2000;28:779–785
  7. Cathcart R, Schwiers E, Saul RL, Ames BN. Thymine glycol and thymidine glycol in human and rat urine. Proc. Natl. Acad. Sci. USA. 1984;81:5633–5637
  8. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 1979;59:527–605
  9. Cooke MS, Evans MD, Herbert KE, Lunec J. Urinary 8-oxo-2′-deoxyguanosine-source, significance and supplements. Free Radical Res. 2000;32:381–397
  10. Cross CE, Halliwell B, Borish ET, Pryar WA, Ames BN, Saul JM, et al. Oxygen radicals and human disease. Ann. Int. Med. 1987;107:526–545
  11. de Souza-Pinto NC, Hogue BA, Bohr VA. DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radical Biol. Med. 2001;30:916–923
  12. Dizdaroglu M. Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on γ-irradiation in aqueous solution. Biochemistry. 1985;24:4476–4481
  13. Dreher D, Junod AF. Role of oxygen-free radicals in cancer development. Eur. J. Cancer A. 1996;32:30–38
  14. Feig DI, Loeb LA. Oxygen radical induced mutagenesis is DNA polymerase specific. J. Mol. Biol. 1994;235:33–41
  15. Fraga CG, Shigenaga MK, Park J-W, Degan P, Ames BN. Oxidative damage to DNA during ageing: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA. 1990;87:4533–4537
  16. Halliwell B, Aruoma OI. DNA and Free Radicals. Chichester, UK: Ellis Harwood; 1993;
  17. Kaneko T, Tahara S, Matsuo M. Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging. Mutat. Res. 1996;316:277–285
  18. Kaneko T, Tahara S. Formation of 8-oxo-2′-deoxyguanosine in the DNA of human diploid fibroblasts by treatment with linoleic acid hydroperoxide and ferric ion. Lipids. 2000;35:961–965
  19. Kasai H, Tanooka H, Nishimura S. Formation of 8-hydroxyguanine residues in DNA by X-irradiation. Gann. 1984;75:1037–1039
  20. Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986;7:1849–1851
  21. Kohda H, Nakagawa T, Kawazoe Y. Singlet oxygen takes part in 8-hydroxydeoxyguanosine formation in deoxyribonucleic acid treated with the horseradish peroxide–H2O2 system. Chem. Pharm. Bull. 1990;38:3072–3075
  22. Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, et al. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature. 1987;327:77–79
  23. Lindhal T. Instability and decay of the primary structure of DNA. Nature. 1993;362:709–715
  24. McGoldrick JP, Yeh YC, Solomon M, Essigman JM, Lu A-L. Characterization of a mammalian homolog of the Escherichia coli Mut Y mismatch repair protein. Mol. Cell. Biol. 1995;15:989–996
  25. Mo J-Y, Maki H, Sekiguchi M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein, sanitization of the nucleotide pool. Proc. Natl. Acad. Sci. USA. 1992;89:11021–11025
  26. Praet M, Calderon PB, Pollakis G, Roberfroid M, Ruysschaert JM. A new class of free radical scavengers reducing adriamycin mitochondrial toxicity. Biochem. Pharmacol. 1988;37:4617–4622
  27. Rosenquist TA, Zharkov DO, Grollman AP. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA. 1997;94:7429–7434
  28. Shen HM, Ong CN. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat. Res. 1996;366:23–44
  29. Shigenaga MK, Gimeno CJ, Ames BN. Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc. Natl. Acad. Sci. USA. 1989;86:9697–9701
  30. Totter JR. Spontaneous cancer and its possible relationship to oxygen metabolism. Proc. Natl. Acad. Sci. USA. 1980;77:1763–1767
  31. Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM. Mechanistic studies of ionizing irradiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry. 1990;29:7024–7032
  32. Yamamoto F, Kasai H, Bessho T, Chung MH, Inoue H, Ohtsuka E, et al. Ubiquitous presence in mammalian cells of enzymatic activity specifically cleaving 8-hydroxyguanine-containing DNA. Jpn. J. Cancer Res. 1992;83:351–357

PII: S0167-4943(02)00056-0

Archives of Gerontology and Geriatrics
Volume 36, Issue 1 , Pages 23-35 , January 2003

Article Tools

* Image Usage & Resolution