Archives of Gerontology and Geriatrics
Volume 51, Issue 2 , Pages 149-151 , September 2010

Incidence of perioperative myocardial infarction and of 2-year mortality in 577 elderly patients undergoing noncardiac vascular surgery treated with and without statins

  • Harit Desai

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Wilbert S. Aronow

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • Corresponding Author InformationCorresponding author at: Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA. Tel.: +1 914 493 5311; fax: +1 914 235 6274.
    • ,
  • Chul Ahn

      Affiliations

    • Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390-8887, USA
    • ,
  • Kaushang Gandhi

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Harshad Amin

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Hoang M. Lai

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Fausan S. Tsai

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Mala Sharma

      Affiliations

    • Cardiology Division, Department of Medicine, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • ,
  • Sateesh Babu

      Affiliations

    • The Department of Surgery, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA
    • Division of Vascular Surgery, New York Medical College, Valhalla, NY 10595, USA

Received 25 June 2009 ,Revised 11 September 2009 ,Accepted 12 September 2009.

References 

  1. Albert MA, Danielson E, Rifai N, Ridker PM. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized and cohort study. J. Am. Med. Assoc. 2001;286:64–70
  2. Aronow WS. Treatment of high-risk older persons with lipid-lowering drug therapy. Am. J. Ther. 2008;15:102–107
  3. Aronow WS, Ahn C. Incidence of new coronary events in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol ≥125mg/dl treated with statins versus no lipid-lowering drug. Am. J. Cardiol. 2002;89:67–69
  4. Aronow WS, Ahn C. Frequency of new coronary events in older persons with peripheral arterial disease and serum low-density lipoprotein cholesterol ≥125mg/dl treated with statins versus no lipid-lowering drug. Am. J. Cardiol. 2002;90:789–791
  5. Durazzo AES, Machado FS, Ikeoka DT, De Bernoche C, Monachini MC, Puech-Leao P, et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial. J. Vasc. Surg. 2004;39:967–976
  6. Kertai MD, Boersma E, Westerhout CM, Domburg RV, Klein J, Bax JJ, et al. Association between long-term statin use and mortality after successful abdominal aortic aneurysm surgery. Am. J. Med. 2004;116:96–103
  7. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–1143
  8. O’Driscoll G, Green D, Taylor RR. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation. 1997;95:1126–1131
  9. O’Neil-Callahan K, Katsimaglia MR, Ryan J, Mosby C, Ioannidis JPA, Danias PG. Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery. The Statins for Risk Reduction in Surgery (StaRRS) Study. J. Am. Coll. Cardiol. 2005;45:336–342
  10. Poldermans D, Bax JJ, Kertai MD, Krenning B, Westerhout CM, Schinkel AFL, et al. Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery. Circulation. 2003;107:1848–1851
  11. Rosenson RS, Tangney CC. Antiatherothrombotic properties of statins: implications for cardiovascular event reduction. J. Am. Med. Assoc. 1998;279:1643–1650
  12. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 2001;21:1712–1719
  13. Undas A, Brummel KE, Musial J, Mann KG, Szczeklik A. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation. Circulation. 2001;103:2248–2253
  14. Undas A, Brozek J, Musial J. Anti-inflammatory and antithrombotic effects of statins in the management of coronary artery disease. Clin. Lab. 2002;48:287–296

PII: S0167-4943(09)00242-8

doi: 10.1016/j.archger.2009.09.042

Archives of Gerontology and Geriatrics
Volume 51, Issue 2 , Pages 149-151 , September 2010

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