Archives of Gerontology and Geriatrics
Volume 51, Issue 2 , Pages 164-168 , September 2010

Association between C-reactive protein (CRP) level and physical performance in community-dwelling elderly in Japan

  • Yuko Yoshida

      Affiliations

    • Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 3964 3241; fax: +81 3 3964 2316.
    • ,
  • Hajime Iwasa

      Affiliations

    • Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan
    • ,
  • Shu Kumagai

      Affiliations

    • University of Human Arts and Sciences, 1288 Magome, Iwatsuki-shi, Saitama, 339-8539, Japan
    • ,
  • Hideyo Yoshida

      Affiliations

    • Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan
    • ,
  • Takao Suzuki

      Affiliations

    • Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan

Received 16 April 2009 ,Revised 18 September 2009 ,Accepted 1 October 2009.

References 

  1. Al Snih S, Markides KS, Ottenbacher KJ, Raji MA. Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period. Aging Clin. Exp. Res. 2004;16:481–486
  2. Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation. 2003;108:2317–2322
  3. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J. Gerontol. A: Biol. Sci. Med. Sci. 2004;59:242–248
  4. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am. J. Med. 2008;121:219–225
  5. Chirinos JA, Zambrano JP, Chakko S, Schob A, Veerani A, Perez GO, et al. Usefulness of C-reactive protein as an independent predictor of death in patients with ischemic cardiomyopathy. Am. J. Cardiol. 2005;95:88–90
  6. Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J. Am. Geriatr. Soc. 2002;50:1947–1954
  7. Freeman DJ, Norrie J, Caslake MJ, Gaw A, Ford I, Lowe GD, et al. C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes. 2002;51:1596–1600
  8. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 1999;340:448–454
  9. Giampaoli S, Ferrucci L, Cecchi F, Lo Noce C, Poce A, Dima F, et al. Hand-grip strength predicts incident disability in non-disabled older men. Age Ageing. 1999;28:283–288
  10. Haddad F, Zaldivar F, Cooper DM, Adams GR. IL-6-induced skeletal muscle atrophy. J. Appl. Physiol. 2005;98:911–917
  11. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger , et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 1999;106:506–512
  12. Koenig W, Khuseyinova N, Baumert J, Meisinger C. Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984–1998. Clin. Chem. 2008;54:335–342
  13. Kuo HK, Bean JF, Yen CJ, Leveille SG. Linking C-reactive protein to late-life disability in the National Health and Nutrition Examination Survey (NHANES) 1999–2002. J. Gerontol. A: Biol. Sci. Med. Sci. 2006;61:380–387
  14. Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J. Am. Geriatr. Soc. 2007;55:864–871
  15. Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yang G, et al. Serum C-reactive protein even at very low (<1.0mg/l) concentration is associated with physical performance in a community-based elderly population aged 70 years and over. Gerontology. 2008;54:260–267
  16. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N. Engl. J. Med. 2004;351:2599–2610
  17. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  18. Penninx BW, Kritchevsky SB, Newman AB, Nicklas BJ, Simonsick EM, Rubin S, et al. Inflammatory markers and incident mobility limitation in the elderly. J. Am. Geriatr. Soc. 2004;52:1105–1113
  19. Rolland Y, Lauwers-Cances V, Cesari M, Vellas B, Pahor M, Grandjean H. Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur. J. Epidemiol. 2006;21:113–122
  20. Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am. J. Med. 2006;119:526.e9–526.e17
  21. Shinkai S, Watanabe S, Kumagai S, Fujiwara Y, Amano H, Yoshida H, et al. Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing. 2000;29:441–446
  22. Suzuki T, Shibata H. An introduction of the Tokyo Metropolitan Institute of Gerontology Longitudinal Interdisciplinary Study on Aging (TMIG-LISA, 1991–2001). Geriatr. Gerontol. Int. 2003;3(Suppl.):S1–S4
  23. Suzuki T, Yoshida H, Kim H, Yukawa H, Sugiura M, Furuna T, et al. Walking speed as a good predictor for maintenance of I-ADL among the rural community elderly in Japan: a 5-year follow-up study from TMIG-LISA. Geriatr. Gerontol. Int. 2003;3(Suppl.):S6–S14
  24. Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J. Gerontol. A: Biol. Sci. Med. Sci. 2000;55:M709–M715
  25. Toth MJ, Ades PA, Tischler MD, Tracy RP, LeWinter MM. Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure. Int. J. Cardiol. 2006;109:179–187
  26. Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J. Gerontol. A: Biol. Sci. Med. Sci. 2002;57:M326–M332
  27. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch. Intern. Med. 2002;162:2333–2341

PII: S0167-4943(09)00257-X

doi: 10.1016/j.archger.2009.10.002

Archives of Gerontology and Geriatrics
Volume 51, Issue 2 , Pages 164-168 , September 2010

Article Tools

* Image Usage & Resolution